スタッフ紹介

助教桂田 武彦

Takehiko Katsurada

専門分野

炎症性腸疾患の診断、治療

助教 桂田 武彦

学歴

1992年3月
北海道札幌南高等学校卒業
1999年3月
北海道大学医学部医学科卒業
2008年3月
北海道大学大学院医学研究科医学博士課程修了

職務経歴

1999年6月
北海道大学医学部附属病院 内科ローテート
2000年4月
苫小牧王子総合病院 内科研修医
2000年10月
北海道社会保険病院循環器内科 研修医
2001年4月
市立稚内病院内科 医師
2002年4月
札幌北楡病院消化器内科 医師
2008年4月
北海道大学第三内科助教
2012年4月
北海道大学病院・消化器内科・助教(科名変更)
2014年10月
北海道大学病院・光学医療診療部・助教

プロフィール

9歳で潰瘍性大腸炎を発症。北海道大学在学中に増悪し第三内科に入院歴をもつ。研修医、レジデントを経て大学院卒業後、2008年に炎症性腸疾患グループを新たに設立しグループ長に就任。自らの患者経験に裏打ちされた治療方針のもと、関連病院を含めた全道の炎症性腸疾患診療の標準化を目指し活動している。
「難治性炎症性腸管障害に関する調査研究」(いわゆるIBD班)研究協力者として継続して参加しているほか、2015年度からは「抗菌薬3剤併用による難治性潰瘍性大腸炎の治療」研究班班長を務めた。

所属学会・資格

  • 日本内科学会
  • 日本消化器病学会
  • 日本消化器内視鏡学会
  • 日本消化管学会
  • 日本栄養治療学会
  • 日本炎症性腸疾患学会
  • 日本小腸学会

趣味

酒、歌、ギター、読書

好きな言葉

学ぶとは誠実さを胸に刻むこと、教えるとは共に未来を語ること

受賞歴

  • 2007年 北大第一病理同門会奨励賞(Young Scientist of the Year)
  • 2017年 北海道大学研究総長賞

論文
(英文のみ)

  1. Ito T, Maemoto A, Ueno N, Fujiya M, Ashida T, Hirayama D, Yokoyama Y, Motoya S, Nasuno M, Tanaka H, Katsurada T, Nakase H.
    Long-term drug persistence and clinical outcomes of ustekinumab in Crohn's disease: a multicenter real-world study from the Hokkaido phoenix cohort.
    Crohns Colitis 360. 2026 Jun 19;8(2):otag059.
  2. Otagiri S, Aoyama K, Katsurada T, Ito T, Maemoto A, Orii F, Ashida T, Nasuno M, Tanaka H, Ando K, Fujiya M, Yokoyama Y, Motoya S, Nakase H.
    Short- and Long-Term Effectiveness and Safety of Vedolizumab in Crohn's Disease: A Multicenter Retrospective Study from the Hokkaido Phoenix Cohort.
    Inflamm Intest Dis. 2026 Apr 28;11(1):232-243.
  3. Fukushima S, Katsurada T, Ito T, Maemoto A, Orii F, Ashida T, Nasuno M, Tanaka H, Ando K, Fujiya M, Yokoyama Y, Motoya S, Nakase H.
    Long-Term Outcomes and Prognostic Factors for Vedolizumab-Treated Japanese Patients with Ulcerative Colitis.
    Inflamm Intest Dis. 2025 Nov 24;11(1):1-10.
  4. Aoyama K, Yamamura R, Katsurada T, Shimizu T, Takahashi D, Kondo E, Iwasaki N, Tamakoshi A, Soga T, Fukuda S, Sonoshita M, Sakamoto N.
    Decreased Fecal Nicotinamide and Increased Bacterial Nicotinamidase Gene Expression in Ulcerative Colitis Patients.
    Inflamm Bowel Dis. 2025 Oct 1;31(10):2815-2825.
  5. Kinoshita K, Sawaguchi S, Toyoshima K, Yoshida S, Yamamura T, Nagai K, Tanaka I, Hatanaka K, Yamamoto Y, Naruse H, Katsurada T, Sakamoto N.
    Novel desensitization therapy of mesalamine intolerance in patients with ulcerative colitis.
    Gastroenterol Hepatol. 2025 Aug-Sep;48(7):502347. English, Spanish.
  6. Ando K, Fujiya M, Ueno N, Ito T, Maemoto A, Nasuno M, Tanaka H, Sakurai K, Katsurada T, Orii F, Ashida T, Motoya S, Kazama T, Yokoyama Y, Hirayama D,Nakase H.
    Effectiveness and Persistency of Ustekinumab Treatment for Ulcerative Colitis: A Phoenix retrospective Cohort Study.
    Crohns Colitis 360. 2024 Apr 13;6(2):otae024.
  7. Fukushima S, Katsurada T, Nishida M, Omotehara S, Sakurai K, Yamanashi K,Onishi R, Sakamoto N.
    Effectiveness of transabdominal ultrasonography in predicting clinical relapse of Crohn's disease.
    Intest Res. 2024 Jan;22(1):82-91.
  8. Hirayama D, Motoya S, Ashida T, Ando K, Fujiya M, Ito T, Furukawa S, Maemoto A, Katsurada T, Hinotsu S, Sato N, Mizuno N, Ikawa Y, Nakase H.
    Effectiveness and Factors Associated with Response to Golimumab in Japanese Patients with Ulcerative Colitis in Real Clinical Practice: The Phoenix Study.
    Inflamm Intest Dis. 2023 Aug 31;8(3):115-127.
  9. Yamasaki T, Nagata N, Atsumi T, Hasebe R, Tanaka Y, Ohki I, Kubota S, Shinohara Y, Bin Teoh Y, Yokoyama N, Sasaki N, Nakamura K, Ohta H, Katsurada T, Matsuno Y, Hojyo S, Hashimoto S, Takiguchi M, Murakami M.
    Zoobiquity experiments show the importance of the local MMP9-plasminogen axis in inflammatory bowel diseases in both dogs and patients.
    Int Immunol. 2023 Jul 7;35(7):313-326.
  10. Sakurai K, Katsurada T, Nishida M, Omotehara S, Fukushima S, Otagiri S, Nagashima K, Onishi R, Takagi R, Komatsu Y, Sakamoto N.
    Characteristics and usefulness of transabdominal ultrasonography in immune-mediated colitis.
    Intest Res. 2023 Jan;21(1):126-136.
  11. Yamanashi K, Katsurada T, Nishida M, Onishi R, Omotehara S, Otagiri S, Sakurai K, Nagashima K, Kinoshita K, Takagi R, Sakamoto N.
    Crohn's Disease Activity Evaluation by Transabdominal Ultrasonography: Correlation with Double-Balloon Endoscopy.
    J Ultrasound Med. 2021 Dec;40(12):2595-2605.
  12. Suzuki K, Kakuta Y, Naito T, Takagawa T, Hanai H, Araki H, Sasaki Y, Sakuraba H, Sasaki M, Hisamatsu T, Motoya S, Matsumoto T, Onodera M, Ishiguro Y,Nakase H, Andoh A, Hiraoka S, Shinozaki M, Fujii T, Katsurada T, Kobayashi T, Fujiya M, Otsuka T, Oshima N, Suzuki Y, Sato Y, Hokari R, Noguchi M, Ohta Y, Matsuura M, Kawai Y, Tokunaga K, Nagasaki M, Kudo H, Minegishi N, Okamoto D, Shimoyama Y, Moroi R, Kuroha M, Shiga H, Li D, McGovern DPB, Kinouchi Y, Masamune A; MENDEL study group.
    Genetic Background of Mesalamine-induced Fever and Diarrhea in Japanese Patients with Inflammatory Bowel Disease.
    Inflamm Bowel Dis. 2022 Jan 5;28(1):21-31.
  13. Sakurai K, Furukawa S, Katsurada T, Otagiri S, Yamanashi K, Nagashima K, Onishi R, Yagisawa K, Nishimura H, Ito T, Maemoto A, Sakamoto N.
    Effectiveness of administering zinc acetate hydrate to patients with inflammatory bowel disease and zinc deficiency: a retrospective observational two-center study.
    Intest Res. 2022 Jan;20(1):78-89.
  14. Otagiri S, Ohnishi S, Ohara M, Fu Q, Yamamoto K, Yamamoto K, Katsurada T, Sakamoto N.
    Oleoylethanolamide Ameliorates Dextran Sulfate Sodium-Induced Colitis in Rats.
    Front Pharmacol. 2020 Aug 14;11:1277.
  15. Ito T, Maemoto A, Katsurada T, Tanaka H, Motoya S, Ueno N, Fujiya M, Ashida T, Hirayama D, Nakase H.
    Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn's Disease: A Retrospective Cohort Study.
    Crohns Colitis 360. 2020 Jul 28;2(4):otaa061.
  16. Kitagataya T, Suda G, Nagashima K, Katsurada T, Yamamoto K, Kimura M, Maehara O, Yamada R, Shigesawa T, Suzuki K, Nakamura A, Ohara M, Umemura M, Kawagishi N, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Ohnishi S, Komatsu Y, Hata H, Takeuchi S, Abe T, Sakakibara-Konishi J, Teshima T, Homma A, Sakamoto N.
    Prevalence, clinical course, and predictive factors of immune checkpoint inhibitor monotherapy-associated hepatitis in Japan.
    J Gastroenterol Hepatol. 2020 Oct;35(10):1782-1788.
  17. Higashiyama M, Sugita A, Koganei K, Wanatabe K, Yokoyama Y, Uchino M, Nagahori M, Naganuma M, Bamba S, Kato S, Takeuchi K, Omori T, Takagi T, Matsumoto S, Nagasaka M, Sagami S, Kitamura K, Katsurada T, Sugimoto K, Takatsu N, Saruta M, Sakurai T, Watanabe K, Nakamura S, Suzuki Y, Hokari R.
    Management of elderly ulcerative colitis in Japan.
    J Gastroenterol. 2019 Jul;54(7):571-586.
  18. Omotehara S, Nishida M, Kinoshita K, Onishi R, Onodera A, Suya M, Hasegawa T, Mitsumori D, Katsurada T, Teshima T.
    Validation of US evaluation of ulcerative colitis activity.
    Ultrasound Med Biol. 2019 Jul;45(7):1537-1544.
  19. Kinoshita K, Katsurada T, Nishida M, Omotehara S, Onishi R, Mabe K, Onodera A, Sato M, Eto K, Suya M, Maemoto A, Hasegawa T, Yamamoto J, Mitsumori D, Yoshii S, Ono K, Sakamoto N.
    Usefulness of transabdominal ultrasonography for assessing ulcerative colitis: a prospective, multicenter study.
    J Gastroenterol. 2019 Jun;54(6):521-529.
  20. Otagiri S, Ohnishi S, Miura A, Hayashi H, Kumagai I, Ito YM, Katsurada T, Nakamura S, Okamoto R, Yamahara K, Cho KY, Isoe T, Sato N, Sakamoto N.
    Evaluation of amnion-derived mesenchymal stem cells for treatment-resistant moderate Crohn's disease: study protocol for a phase I/II, dual-centre, open- label, uncontrolled, dose-response trial.
    BMJ Open Gastroenterol. 2018 May 31;5(1):e000206.
  21. Tsuda M, Ohnishi S, Mizushima T, Hosono H, Yamahara K, Ishikawa M, Abiko S, Katsurada T, Shimizu Y, Sakamoto N.
    Preventive effect of mesenchymal stem cell culture supernatant on luminal stricture after endoscopic submucosal dissection in the rectum of pigs.
    Endoscopy. 2018 Oct;50(10):1001-1016.
  22. Miyamoto S, Ohnishi S, Onishi R, Tsuchiya I, Hosono H, Katsurada T, Yamahara K, Takeda H, Sakamoto N.
    Therapeutic effects of human amnion-derived mesenchymal stem cell transplantation and conditioned medium enema in rats with trinitrobenzene sulfonic acid-induced colitis.
    Am J Transl Res. 2017 Mar 15;9(3):940-952.
  23. Onishi R, Ohnishi S, Higashi R, Watari M, Yamahara K, Okubo N, Nakagawa K, Katsurada T, Suda G, Natsuizaka M, Takeda H, Sakamoto N.
    Human Amnion-Derived Mesenchymal Stem Cell Transplantation Ameliorates Dextran Sulfate Sodium-Induced Severe Colitis in Rats.
    Cell Transplant. 2015;24(12):2601-14.
  24. Katsurada T, Kobayashi W, Tomaru U, Baba T, Furukawa S, Ishizu A, Takeda K, Sakamoto N, Asaka M, Takeda H, Kasahara M.
    Decrease of peripheral and intestinal NKG2A-positive T cells in patients with ulcerative colitis.
    PLoS One. 2012;7(9):e44113.
  25. Funakoshi T, Yamashita K, Ichikawa N, Fukai M, Suzuki T, Goto R, Oura T, Kobayashi N, Katsurada T, Ichihara S, Ozaki M, Umezawa K, Todo S.
    A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice.
    J Crohns Colitis. 2012 Mar;6(2):215-25.
  26. Nema H, Kato M, Katsurada T, Nozaki Y, Yotsukura A, Yoshida I, Sato K, Kawai Y, Takagi Y, Okusa T, Takiguchi S, Sakurai M, Asaka M.
    Investigation of gastric and duodenal mucosal defects caused by low-dose aspirin in patients with ischemic heart disease.
    J Clin Gastroenterol. 2009 Feb;43(2):130-2.
  27. Takeda H, Sadakane C, Hattori T, Katsurada T, Ohkawara T, Nagai K, Asaka M.
    Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
    Gastroenterology. 2008 Jun;134(7):2004-13.
  28. Shimizu Y, Kato M, Yamamoto J, Ono Y, Katsurada T, Ono S, Mori Y, Nakagawa M, Nakagawa S, Itoh T, Asaka M.
    Histologic results of EMR for esophageal lesions diagnosed as high-grade intraepithelial squamous neoplasia by endoscopic biopsy.
    Gastrointest Endosc. 2006 Jan;63(1):16-21.