スタッフ紹介
助教/外来医長森川 賢一
Kenichi Morikawa
専門分野
消化器内科学、肝臓病学、
ウイルス肝炎診断・治療
学歴
- 1993年3月
- 愛知県私立東海高等学校卒業
- 1999年3月
- 昭和大学医学部卒業
- 2003年3月
- 昭和大学大学院医学研究科第二内科学講座医学博士課程修了
職務経歴
- 1999年5月
- 昭和大学病院消化器内科 医師
- 2003年4月
- 昭和大学医学部第二内科 員外助教
- 2005年4月
- (財)東京都神経科学総合研究所微生物学部門 流動研究員
- 2006年4月
- 国立感染症研究所ウイルス第二部 流動研究員 及び 財団法人ヒューマンサイエンス財団 流動研究員
- 2007年4月
- 昭和大学医学部第二内科 員外助教 及び 国立感染症研究所ウイルス第二部 協力研究員
- 2008年1月
- 昭和大学医学部内科学講座消化器内科学部門 助教 及び 国立感染症研究所ウイルス第二部 協力研究員
- 2009年8月
- Lausanne大学医学部消化器内科 博士研究員
- 2012年4月
- 昭和大学医学部内科学講座消化器内科学部門 助教
- 2014年10月
- 北海道大学大学院医学研究科内科学講座消化器内科学分野 助教
- 2015年4月
- 北海道大学病院消化器内科 助教
- 2018年4月
- 北海道大学大学院医学研究院消化器内科学教室助教 助教
所属学会・資格
- 日本内科学会 認定内科医
- 日本消化器病学会 専門医・指導医・支部評議員・学会評議員
- 日本肝臓学会 専門医・指導医・東部会評議員・学会評議員
- 日本消化器内視鏡学会 専門医・指導医
- 日本医師会 認定産業医
- 日本ウイルス学会
- ヨーロッパ肝臓学会国際会員
受賞歴
- 2017年 第3回G-PLUS優秀賞
- 2016年 第6回Hepatology Meeting in Japan 2016 最優秀演題賞
- 2016年 第25回アジア太平洋肝臓病学会議年次総会(APASL2016)Presidential Award
- 2014年 Liver Forum in Kyoto研究助成
- 2014年 日本肝臓学会・冠アワード
- 2008年 第44回日本肝臓学会総会会長奨励賞
- 2007年 第4回大正富山アワード
- 2007年 宮川庚子記念財団研究助成
研究費等
国立研究開発法人日本医療研究開発機構(AMED)
- 肝炎等克服実用化研究事業 「肝炎ウイルスの感染複製増殖と病原性発現を阻止するための基盤的研究とその応用のための基盤的開発」 研究分担者(2019年度-2021年度)
- B型肝炎創薬実用化等研究事業 「B型肝炎ウイルスの感染複製増殖機構の解明に関する研究」 研究分担者(2017年度-2021年度)
- 肝炎等克服実用化研究事業 「肝炎ウイルスの感染複製増殖と病原性発現を阻止するための基盤的研究」 研究分担者(2016年度-2018年度)
厚生労働省科学研究費補助金
- B型肝炎創薬実用化等研究事業 「B型肝炎ウイルスの感染複製機構の解明に関する研究」 研究分担者(2012年度-2016年度)
- 肝炎等克服実用化研究事業 「肝炎ウイルスの複製増殖および病原性発現機構と薬剤感受性の解析」 研究分担者(2014年度-2015年度)
文部科学省科学研究費補助金
- 基盤研究(C) 「B型肝炎ウイルス宿主制限因子を標的とした新規抗ウイルス治療の開発」 研究代表者(2020年度-2022年度)
- 基盤研究(B) 「肝硬変の組織学的進展・軽快を担う間質微小環境因子の包括的解析」 研究分担者(2019-2021年度)
- 基盤研究(C) 「レポーターアッセイによる新規・大規模抗HBV薬スクリーニング系を用いた薬剤開発」 研究分担者(2019-2021年度)
- 基盤研究(C) 「B型肝炎ウイルスcccDNA排除を目指した新規抗ウイルス治療の開発」 研究代表者(2017年度-2019年度)
- 挑戦的萌芽研究 「生体高分子シミュレーションによる抗ウイルス薬耐性化仮想アッセイシステムの構築」 研究分担者(2016年度-2017年度)
- 基盤研究(C) 「C末端欠損HBx遺伝子インテグレーションによる肝発癌・悪性化機構の検討」 研究分担者(2016年度-2018年度)
- 基盤研究(B) 「肝硬変の組織病態を修復する新規細胞治療法の探索」 研究分担者(2016年度-2018年度)
- 基盤研究(C) 「C型肝炎ウイルスの粒子形成・分泌機構の解明と関与する細胞性因子の解析」 研究代表者(2014年度-2016年度)
- 若手研究(B) 「C型肝炎ウイルス感染におけるレセプターを含む細胞性因子の関与」 研究代表者(2008年度-2009年度)
- 基盤研究(B) 「C型肝炎ウイルス培養系による感染増殖効率規定因子の解析と新規治療標的候補の探索」 研究分担者(2006年度-2008年度)
- 若手研究(B) 「感染性C型肝炎ウイルス粒子の精製と性状の解析」 研究代表者(2006年度-2007年度)
- 特定領域研究 「感染性C型肝炎ウイルス粒子による肝細胞への遺伝子デリバリーシステムの構築」 研究分担者(2006年度-2007年度)
- 基盤研究(C) 「C型肝炎ウイルス新規感染培養系における、ウイルスadaptationの解析」 研究分担者(2006年度-2007年度)
業績
(英文のみ)
- Koji Ogawa, Takashi Kobayashi, Jun-ichi Furukawa, Hisatoshi Hanamatsu, Akihisa Nakamura, Kazuharu Suzuki, Naoki Kawagishi, Masatsugu Ohara, Machiko Umemura, Masato Nakai, Takuya Sho, Goki Suda, Kenichi Morikawa, Masaru Baba, Ken Furuya, Katsumi Terashita, Tomoe Kobayashi, Manabu Onodera, Takahiro Horimoto, Keisuke Shinada, Seiji Tsunematsu, Izumi Tsunematsu, Takashi Meguro, Tomoko Mitsuhashi, Megumi Hato, Kenichi Higashino, Yasuro Shinohara, Naoya Sakamoto.
Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis: a novel glycobiomarker for non-alcoholic steatohepatitis.
Sci Rep. 2020; 10: 321. Published online 2020 Jan 15. doi: 10.1038/s41598-019-56947-1. PMCID: PMC6962197 - Takuya Sho, Goki Suda, Koji Ogawa, Megumi Kimura, Tomoe Shimazaki, Osamu Maehara, Taku Shigesawa, Kazuharu Suzuki, Akihisa Nakamura, Masatsugu Ohara, Machiko Umemura, Naoki Kawagishi, Mitsuteru Natsuizaka, Masato Nakai, Kenichi Morikawa, Ken Furuya, Masaru Baba, Yoshiya Yamamoto, Tomoe Kobayashi, Takashi Meguro, Akiyoshi Saga, Takuto Miyagishima, Hideki Yokoo, Toshiya Kamiyama, Akinobu Taketomi, Naoya Sakamoto.
Early response and safety of lenvatinib for patients with advanced hepatocellular carcinoma in a real‐world setting.
JGH Open. 2020 Feb; 4(1): 54–60. Published online 2019 Jun 10. doi: 10.1002/jgh3.12209 PMCID: PMC7008153 - Ohara M, Suda G, Kimura M, Maehara O, Shimazaki T, Shigesawa T, Suzuki K, Nakamura A, Kawagishi N, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Kobayashi T, Uebayashi M, Takagi R, Yokota I, Shimamura T, Sakamoto N.
Analysis of the optimal psoas muscle mass index cut-off values, as measured by computed tomography, for the diagnosis of loss of skeletal muscle mass in Japanese people.
Hepatol Res. 2020 Mar 23. doi: 10.1111/hepr.13499. [Epub ahead of print] PMID: 32202371 - Kitagataya T, Suda G, Nagashima K, Katsurada T, Yamamoto K, Kimura M, Maehara O, Yamada R, Shigesawa T, Suzuki K, Nakamura A, Ohara M, Umemura M, Kawagishi N, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Ohnishi S, Komatsu Y, Hata H, Takeuchi S, Abe T, Sakakibara-Konishi J, Teshima T, Homma A, Sakamoto N.
Prevalence, clinical course, and predictive factors of immune checkpoint inhibitor monotherapy-associated hepatitis in Japan.
J Gastroenterol Hepatol. 2020 Mar 18. doi: 10.1111/jgh.15041. [Epub ahead of print] PMID: 32187734 - Sho T, Suda G, Ogawa K, Kimura M, Shimazaki T, Maehara O, Shigesawa T, Suzuki K, Nakamura A, Ohara M, Umemura M, Kawagishi N, Natsuizaka M, Nakai M, Morikawa K, Furuya K, Baba M, Yamamoto Y, Kobayashi T, Meguro T, Saga A, Miyagishima T, Yokoo H, Kamiyama T, Taketomi A, Sakamoto N.
Early response and safety of lenvatinib for patients with advanced hepatocellular carcinoma in a real-world setting.
JGH Open. 2019 Jun 10;4(1):54-60. doi: 10.1002/jgh3.12209. eCollection 2020 Feb. PMID:32055698 - Kawagishi N, Suda G, Kimura M, Maehara O, Shimazaki T, Yamada R, Kitagataya T, Shigesawa T, Suzuki K, Nakamura A, Ohara M, Umemura M, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Kudo Y, Nishida M, Sakamoto N.
High serum angiopoietin-2 level predicts non-regression of liver stiffness measurement-based liver fibrosis stage after direct-acting antiviral therapy for hepatitis C.
Hepatol Res. 2020 Feb 5. doi: 10.1111/hepr.13490. [Epub ahead of print] PMID: 32020702 - Ogawa K, Kobayashi T, Furukawa JI, Hanamatsu H, Nakamura A, Suzuki K, Kawagishi N, Ohara M, Umemura M, Nakai M, Sho T, Suda G, Morikawa K, Baba M, Furuya K, Terashita K, Kobayashi T, Onodera M, Horimoto T, Shinada K, Tsunematsu S, Tsunematsu I, Meguro T, Mitsuhashi T, Hato M, Higashino K, Shinohara Y, Sakamoto N.
Tri-antennary tri-sialylated mono-fucosylated glycan of alpha-1 antitrypsin as a non-invasive biomarker for non-alcoholic steatohepatitis: a novel glycobiomarker for non-alcoholic steatohepatitis.
Sci Rep. 2020 Jan 15;10(1):321. doi: 10.1038/s41598-019-56947-1. PMID:31941930 - Hanamatsu H, Nishikaze T, Tsumoto H, Ogawa K, Kobayashi T, Yokota I, Morikawa K, Suda G, Sho T, Nakai M, Miura N, Higashi-No K, Sekiya S, Iwamoto S, Miura Y, Furukawa JI, Tanaka K, Sakamoto N.
Comparative glycomic analysis of sialyl linkage isomers by sialic acid linkage-specific alkylamidation in combination with stable isotope labeling of α2,3-linked sialic acid residues.
Anal Chem. 2019 Nov 5;91(21):13343-13348. doi: 10.1021/acs.analchem.9b03617. PMID: 31577134 - Sugiura R, Kuwatani M, Nishida M, Hirata K, Sano I, Kato S, Kawakubo K, Nakai M, Sho T, Suda G, Morikawa K, Ogawa K, Sakamoto N.
Correlation between Liver Elasticity by Ultrasound Elastography and Liver Functional Reserve.
Ultrasound Med Biol. 2019 Oct;45(10):2704-2712. doi: 10.1016/j.ultrasmedbio.2019.06.407. PMID: 31300223 - Kobayashi T, Ogawa K, Furukawa JI, Hanamatsu H, Hato M, Yoshinaga T, Morikawa K, Suda G, Sho T, Nakai M, Higashino K, Numata Y, Shinohara Y, Sakamoto N.
Quantifying Protein-Specific N-glycome Profiles by Focused Protein- and Immunoprecipitation-Glycomics.
J Proteome Res. 2019 Aug 2;18(8):3133-3141. doi: 10.1021/acs.jproteome.9b00232. PMID: 31266306 - Suda G, Kimura M, Shigesawa T, Suzuki K, Nakamura A, Ohara M, Kawagishi N, Nakai M, Sho T, Maehara O, Shimazaki T, Morikawa K, Natsuizaka M, Ogawa K, Sakamoto N.
Effects of resistance-associated variants in genotype 2 hepatitis C virus on viral replication and susceptibility to anti-hepatitis C virus drugs.
Hepatol Res. 2019 Nov;49(11):1275-1285. doi: 10.1111/hepr.13401. PMID: 31261439 - Suzuki K, Suda G, Yamamoto Y, Furuya K, Baba M, Kimura M, Maehara O, Shimazaki T, Yamamoto K, Shigesawa T, Nakamura A, Ohara M, Kawagishi N, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N; NORTE Study Group.
Entecavir treatment of hepatitis B virus-infected patients with severe renal impairment and those on hemodialysis.
Hepatol Res. 2019 Nov;49(11):1294-1304. doi: 10.1111/hepr.13399. PMID: 31260579 - Izumi T, Sho T, Morikawa K, Shigesawa T, Suzuki K, Nakamura A, Ohara M, Kawagishi N, Umemura M, Shimazaki T, Kimura M, Nakai M, Suda G, Natsuizaka M, Ogawa K, Kudo Y, Nishida M, Ono K, Baba M, Furuya K, Sakamoto N.
Assessing the risk of hepatocellular carcinoma by combining liver stiffness and the controlled attenuation parameter.
Hepatol Res. 2019 Oct;49(10):1207-1217. doi:10.1111/hepr.13391. PMID:31219667 - Suda G, Hasebe C, Abe M, Kurosaki M, Itakura J, Izumi N, Uchida Y, Mochida S, Haga H, Ueno Y, Abe K, Takahashi A, Ohira H, Tsukuda Y, Furuya K, Baba M, Yamamoto Y, Kobayashi T, Inoue J, Terasita K, Ohara M, Kawagishi N, Izumi T, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N; NORTE Study Group.
Safety and efficacy of glecaprevir and pibrentasvir in Japanese hemodialysis patients with genotype 2 hepatitis C virus infection.
J Gastroenterol. 2019 Feb 18. doi: 10.1007/s00535-019-01556-y. [Epub ahead of print] PMID: 30778716 - Kawagishi N, Suda G, Nakamura A, Kimura M, Maehara O, Suzuki K, Nakamura A, Ohara M, Izumi T, Umemura M, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Kudo Y, Nishida M, Miyoshi H, Sakamoto N.
Liver steatosis and dyslipidemia after HCV eradication by direct acting antiviral agents are synergistic risks of atherosclerosis.
PLoS One. 2018 Dec 21;13(12):e0209615. doi: 10.1371/journal.pone.0209615. eCollection 2018. PMID: 30576386 - Suda G, Nakai M, Sho T, Kimura M, Shimazaki T, Maehara O, Shigesawa T, Suzuki K, Nakamura A, Umemura MOM, Kawagishi N, Baba M, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N; NORTE Study Group.
The Successful Retreatment with Glecaprevir and Pibrentasvir of Genotype 1 or 2 HCV-infected Hemodialysis Patients who Failed to Respond to NS5A and Protease Inhibitor Treatment: A Case Report.
Intern Med. 2018 Dec 18. doi: 10.2169/internalmedicine.2077-18. [Epub ahead of print] PMID: 30568153 - Sho T, Suda G, Kimura M, Shimazaki T, Maehara O, Shigesawa T, Suzuki K, Nakamura A, Ohara M, Umemura M, Izumi T, Kawagishi N, Baba M, Nakai M, Natsuizka M, Morikawa K, Ogawa K, Sakamoto N; NORTE Study Group.
Glecaprevir and Pibrentasvir for Japanese Patients with Human Immunodeficiency Virus and Genotype 3 Hepatitis C Virus Coinfection: A Report of Three Cases.
Intern Med. 2018 Nov 19. doi: 10.2169/internalmedicine.1856-18. [Epub ahead of print] PMID: 30449808 - Morikawa K, Nakamura A, Shimazaki T, Sakamoto N.
Safety and efficacy of elbasvir/grazoprevir for the treatment of chronic hepatitis C: current evidence.
Drug Des Devel Ther. 2018 Sep 5;12:2749-2756. doi: 10.2147/DDDT.S133697. eCollection 2018. Review. PMID: 30233138 - Ohara M, Ogawa K, Suda G, Kimura M, Maehara O, Shimazaki T, Suzuki K, Nakamura A, Umemura M, Izumi T, Kawagishi N, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ohnishi S, Sakamoto N.
L-Carnitine Suppresses Loss of Skeletal Muscle Mass in Patients With Liver Cirrhosis.
Hepatol Commun. 2018 Aug 6;2(8):906-918. doi: 10.1002/hep4.1207. eCollection 2018 Aug. PMID: 30094402 - Suda G, Kurosaki M, Itakura J, Izumi N, Uchida Y, Mochida S, Hasebe C, Abe M, Haga H, Ueno Y, Masakane I, Abe K, Takahashi A, Ohira H, Furuya K, Baba M, Yamamoto Y, Kobayashi T, Kawakami A, Kumagai K, Terasita K, Ohara M, Kawagishi N, Umemura M, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N; NORTE Study Group.
Safety and efficacy of elbasvir and grazoprevir in Japanese hemodialysis patients with genotype 1b hepatitis C virus infection.
J Gastroenterol. 2018 Jul 17. doi: 10.1007/s00535-018-1495-6. [Epub ahead of print] PMID: 30019127 - Cai C, Koch B, Morikawa K, Suda G, Sakamoto N, Rueschenbaum S, Akhras S, Dietz J, Hildt E, Zeuzem S, Welsch C, Lange CM.
Macrophage-Derived Extracellular Vesicles Induce Long-Lasting Immunity Against Hepatitis C Virus Which Is Blunted by Polyunsaturated Fatty Acids.
Front Immunol. 2018 Apr 12;9:723. doi: 10.3389/fimmu.2018.00723. eCollection 2018. PMID: 29706960 - Doi H, Hayashi E, Arai J, Tojo M, Morikawa K, Eguchi J, Ito T, Kanto T, Kaplan DE, Yoshida H.
Enhanced B-cell differentiation driven by advanced cirrhosis resulting in hyperglobulinemia.
J Gastroenterol Hepatol. 2018 Feb 10. doi: 10.1111/jgh.14123. [Epub ahead of print] PMID: 29427373 - Sho T, Suda G, Nagasaka A, Yamamoto Y, Furuya K, Kumagai K, Uebayashi M, Terashita K, Kobayashi T, Tsunematsu I, Onodera M, Meguro T, Kimura M, Ito J, Umemura M, Izumi T, Kawagishi N, Ohara M, Ono Y, Nakai M, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N; NORTE Study Group.
Safety and efficacy of sofosbuvir and ribavirin for genotype 2 hepatitis C Japanese patients with renal dysfunction.
Hepatol Res. 2018 Jun;48(7):529-538. doi: 10.1111/hepr.13056. Epub 2018 Feb 15. PMID: 29316051 - Suda G, Ogawa K, Morikawa K, Sakamoto N.
Treatment of hepatitis C in special populations.
J Gastroenterol. 2018 May;53(5):591-605. doi: 10.1007/s00535-017-1427-x. Epub 2018 Jan 3. Review. PMID: 29299684 - Nakai M, Ogawa K, Takeda R, Ohara M, Kawagishi N, Izumi T, Umemura M, Ito J, Sho T, Suda G, Morikawa K, Sakamoto N.
Increased serum C-reactive protein and decreased urinary aquaporin 2 levels are predictive of the efficacy of tolvaptan in patients with liver cirrhosis.
Hepatol Res. 2018 Feb;48(3): E311-E319. doi: 10.1111/hepr.12988. Epub 2017 Nov 3. PMID: 28984014 - Maehara O, Suda G, Natsuizaka M, Ohnishi S, Komatsu Y, Sato F, Nakai M, Sho T, Morikawa K, Ogawa K, Shimazaki T, Kimura M, Asano A, Fujimoto Y, Ohashi S, Kagawa S, Kinugasa H, Naganuma S, Whelan KA, Nakagawa H, Nakagawa K, Takeda H, Sakamoto N.
Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma.
Carcinogenesis. 2017 Oct 26;38(11):1073-1083. doi: 10.1093/carcin/bgx095. PMID: 28927233 - Suda G, Ito J, Nagasaka A, Yamamoto Y, Furuya K, Okamoto M, Terashita K, Kobayashi T, Tsunematsu I, Yoshida J, Meguro T, Ohara M, Kawagishi N, Kimura M, Umemura M, Izumi T, Tsukuda Y, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N; NORTE Study Group.
Add-on effects of fluvastatin in simeprevir/pegylated-interferon/ribavirin combination therapy for patients with genotype 1 hepatitis C virus infection: a randomized controlled study.
Hepatol Res. 2018 Feb;48(3):E146-E154. doi: 10.1111/hepr.12938. Epub 2017 Aug 10. PMID: 28722780 - Kawagishi N, Suda G, Onozawa M, Kimura M, Maehara O, Ohara M, Izumi T, Umemura M, Ito J, Nakai M, Sho T, Natsuizka M, Morikawa K, Ogawa K, Sakamoto N.
Comparing the risk of hepatitis B virus reactivation between direct-acting antiviral therapies and interferon-based therapies for hepatitis C.
J Viral Hepat. 2017 Dec;24(12):1098-1106. doi: 10.1111/jvh.12737. PMID: 28632923 - Sho T, Nakanishi M, Morikawa K, Ohara M, Kawagishi N, Izumi T, Umemura M, Ito J, Nakai M, Suda G, Ogawa K, Chuma M, Meguro T, Nakamura M, Nagasaka A, Horimoto H, Yamamoto Y, Sakamoto N.
A Phase I Study of Combination Therapy with Sorafenib and 5-Fluorouracil in Patients with Advanced Hepatocellular Carcinoma.
Drugs R D. 2017 Sep;17(3):381-388. doi: 10.1007/s40268-017-0187-7. PMID: 28573606 - Suda G, Furusyo N, Toyoda H, Kawakami Y, Ikeda H, Suzuki M, Arataki K, Mori N, Tsuji K, Katamura Y, Takaguchi K, Ishikawa T, Tsuji K, Shimada N, Hiraoka A, Yamsaki S, Nakai M, Sho T, Morikawa K, Ogawa K, Kudo M, Nagasaka A, Furuya K, Yamamoto Y, Kato K, Ueno Y, Iio E, Tanaka Y, Kurosaki M, Kumada T, Chayama K, Sakamoto N.
Daclatasvir and asunaprevir in hemodialysis patients with hepatitis C virus infection: a nationwide retrospective study in Japan.
J Gastroenterol. 2018 Jan;53(1):119-128. doi:10.1007/s00535-017-1353-y. PMID:28560477 - Yoshikawa A, Terashita K, Morikawa K, Matsuda S, Yamamura T, Sarashina K, Nakano S, Kobayashi Y, Sogabe S, Takahashi K, Haba S, Oda H, Takahashi T, Miyagishima T, Sakamoto N.
Interferon-free therapy with sofosbuvir plus ribavirin for successful treatment of genotype 2 hepatitis C virus with lichen planus: a case report.
Clin J Gastroenterol. 2017 Jun; 10(3):270-273. doi: 10.1007/s12328-017-0742-3. PMID: 28447325 - Kawagishi N, Suda G, Onozawa M, Kimura M, Maehara O, Ito J, Nakai M, Sho T, Natsuizka M, Morikawa K, Ogawa K, Sakamoto N.
Hepatitis B virus reactivation during hepatitis C direct-acting antiviral therapy in patients with previous HBV infection.
J Hepatol. 2017 Nov;67(5):1106-1108. doi: 10.1016/j.jhep.2017.04.008. PMID: 28438688 - Suda G, Ogawa K, Yamamoto Y, Katagiri M, Furuya K, Kumagai K, Konno J, Kimura M, Kawagishi N, Ohara M, Umemura M, Ito J, Izumi T, Nakai M, Sho T, Natsuizaka M, Morikawa K, Tsubota A, Shimada N, Iio E, Tanaka Y, Sakamoto N; NORTE Study Group.
Retreatment with sofosbuvir, ledipasvir, and add-on ribavirin for patients who failed daclatasvir and asunaprevir combination therapy.
J Gastroenterol. 2017 Oct;52(10):1122-1129. doi: 10.1007/s00535-017-1328-z. PMID: 28315983 - Suda G, Ogawa K, Kimura M, Nakai M, Sho T, Morikawa K, Sakamoto N.
Novel Treatment of Hepatitis C Virus Infection for Patients with Renal Impairment.
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Safety and efficacy of daclatasvir and asunaprevir in hepatitis C virus infected patients with renal impairment.
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Combination of neutrophil-to-lymphocyte ratio and early des-gamma-carboxyprothrombin change ratio as a useful predictor of treatment response for hepatic arterial infusion chemotherapy against advanced hepatocellular carcinoma.
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Prevalence and characteristics of naturally occurring sofosbuvir resistance-associated variants in patients with hepatitis C virus genotype 1b infection.
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Viral life cycle of hepatitis B virus: host factors and druggable targets.
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A pivotal role of Krüppel-like factor 5 in regulation of cancer stem-like cells in hepatocellular carcinoma.
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Increased expression of immuno-inhibitory molecules on peripheral blood lymphocytes may suppress disease progression in autoimmune hepatitis.
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Vitamin D Receptor and Jak-STAT Signaling Crosstalk Results in Calcitriol-Mediated Increase of Hepatocellular Response to IFN-α.
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Quantitative proteomics identifies the membrane-associated peroxidase GPx8 as a cellular substrate of the hepatitis C virus NS3-4A protease.
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Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development.
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Neutralizing antibodies induced by cell culture-derived hepatitis C virus protect against infection in mice.
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Lymphotropic Hepatitis C Virus Has an Interferon-Resistant Phenotype.
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Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.
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Nonstructural protein 3-4A: the Swiss army knife of hepatitis C virus.
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Infection of B cells with hepatitis C virus for the development of lymphoproliferative disorders in patients with chronic hepatitis C.
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Magnitude of CD8 T-cell responses against hepatitis C virus and severity of hepatitis do not necessarily determine outcomes in acute hepatitis C virus infection.
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Trans-encapsidation of hepatitis C virus subgenomic replicon RNA with viral structure proteins.
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Critical role of virion-associated cholesterol and sphingolipid in hepatitis C virus infection.
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The NS3 helicase and NS5B-to-3'X regions are important for efficient hepatitis C virus strain JFH-1 replication in Huh7 cells.
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The roles of CD81 and glycosaminoglycans in the adsorption and uptake of infectious HCV particles.
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An infectious and selectable full-length replicon system with hepatitis C virus JFH-1 strain.
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CD81 expression is important for the permissiveness of Huh7 cell clones for heterogeneous hepatitis C virus infection.
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Cell culture and infection system for hepatitis C virus.
Nat Protoc. 2006; 1(5):2334-9. PMID: 17406476 - Morikawa K, Ito T, Nozawa H, Inokuchi M, Uchikoshi M, Saito T, Mitamura K, Imawari M.
Translational enhancement of HCV RNA genotype 1b by 3'-untranslated and envelope 2 protein-coding sequences.
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Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b.
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