業績

2015年度 :: 学会発表 :: 国際学会 :: 業績

25th APASL Conference
2016.2. Tokyo, Japan


Karino Y, Chayama K, Burroughs MH, Ikeda K, Suzuki F, Toyoda H, Sato K, Matsuzaki Y, Kioka K, Zhang X, Rodrigues-Jr L, Kumada H.
GIFT-I: Ombitasvir/Paritaprevir/Ritonavir safety and efficacy in renally-impaired japanese patients.

Karino Y, Nakajima T, Yamaguchi M, Kimura M, Arakawa T, Kuwata Y, Ozeki I, Sato T, Ohmura T, Hige S, Toyota J.
Change of AFP level according to the stage of liver disease during Daclatasvir/Asaunaprevir therapy.

Morikawa K.
Analysis of cellular factors involved in the particle formation and secretion of hepatitis C virus.


Hige S, Ozeki I, Yamaguchi M, Kimura M, Arakawa T, Nakajima T, Kuwata Y, Sato T, Ohmura T, Toyota J, Karino Y.
Resistance-associated variants in hepatitis C patients who failed direct acting antiviral treatment.

Ito J, Suda G, Yamamoto Y, Nagasaka A, Furuya K, Kumagai K, Kikuchi H, Miyagishima T, Kobayashi T, Kimura M, Yamasaki K, Umemura M, Izumi T, Tsunematsu S, Sato F, Tsukuda Y, Terashita K, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N.
Prevalence and characteristics of naturally occurring sofosbuvir resistance-associated variants.

Sato T, Kitagawa S, Kimura M.
Treatments of bleeding portal hypertensive duodenopathy.

2016 Gastrointestinal Cancers Symposium
2016.1. San Francisco, USA


Ishiguro A, Nakamura M, Muranaka T, Yuki S, Murai T, Matsuda C, Oba A, Itaya K, Shigesawa T, Koike Y, Fujita Y, Endo A, Tsukuda Y, Ono Y, Kudo T, Nagasaka A, Nishikawa S, Komatsu Y.
Prospective observational study for the impact of short- term periodic intravenous steroid premedication for gastrointestinal cancer chemotherapy on bone metabolism. (ESPRESSO-01)

Muranaka T, Yuki S, Sawada K, Kawamoto Y, Nakatsumi H, Dazai M, Hayasi H, Nakamura M, Ishiguro A, Sogabe S, Kobayashi Y, Miyagishima T, Iwanaga I, Tateyama M, Hatanaka K, Kato T, Sakamoto N, Sakata Y, Komatsu Y.
Trial in Progress : Phase II trial of bolus 5-FU/l-LV regimen as salvage line chemotherapy for oral fluorouracil resistant unresectable gastric cancer (HGCSG1502).

Nakamura M, Yuki S, Sawada K, Oba A, Sato A, Kato T, Megura T, Ehira N, Tateyama M, Hatanaka K, Eto K, Okuda H, Kobayashi Y, Muto O, Abe M, Kato K, Kudo M, Miyashita K, Sakata Y, Komatsu Y.
Updated analysis : Observational cohort study of 1st line bevacizumab combined with chemotherapy in metastatic colorectal cancer (HGCSG0802) :Sub-group analysis by KRAS exon 2 status.

Oba A, Nakamura M, Murai T, Matsuda C, Itaya K, Koike Y, Endo A, Tsukuda Y, Ono Y, Kudo T, Nagasaka A, Nishikawa S.
Thromboembolism incidence in patients with gastrointestinal tract cancer receiving chemotherapy: A single-institutional retrospective cohort analysis.

Yuki S, Nakatsumi H, Sawada K, Kato T, Meguro T, Nakamura M, Iwanaga I, Ehira N, Sonoda N, Kudo M, Kato K, Sogabe S, Amano T, Ono K, Sakamoto K, Miyamoto N, Kudo K, Sakamoto N, Sakata Y, Komatsu Y.
Observational cohort study of first-line bevacizumab with oxaliplatin or irinotecan and fluoropyrimidines in metastatic colorectal cancer : HGCSG0802 : Analysis of early tumor shrinkage (ETS).

ESMO ASIA 2015
2015.12. Singapore, Singapore


Dazai M, Yuki S, Muranaka T, Yoshida S, Ohta Y, Hatanaka K, Tsuji Y, Ohta T, Sato A, Eto K, Onodera K, Sato Y, Kato K, Nakamura M, Muto O, Ishiguro S, Tateyama M, Okuda H, Sakata Y, Komatsu Y.
A retrospective cohort study evaluating the safety and efficacy of regorafenib in patients with metastatic colorectal cancer : the HGCSG1401 study -first report-

Kawamoto Y, Komatsu Y, Yuki S, Sawada K, Muranaka T, Nakatsumi H, Fukushima H, Ishiguro A, Dazai M, Hatanaka K, Nakamura M, Iwanaga I, Uebayashi M, Sogabe S, Miyagishima T, Ono K, Sakamoto N, Sakata Y.
Phase I/II trial of combined chemotherapy of S-1, nab- paclitaxel and oxaliplatin administered biweekly for patients with advanced gastric cancer (HGCSG1404; SNOW study).

Komatsu Y, Yuki S, Nakatsumi H, Sawada K, Hatanaka K, Kato T, Meguro T, Nakamura M, Iwanaga I, Uebayashi M, Tateyama M, Eto K, Kudo M, Kato K, Okuda H, Sogabe S, Miyagishima T, Miyashita K, Sakamoto N, Sakata Y.
Updated analysis : Observational cohort study of 1st line bevacizumab combined with chemotherapy in metastatic colorectal cancer (HGCSG0802): Comparison of infusional FU/Oxaliplatin(OX)+BV and oral FU/OX+BV.

Yuki S, Komatsu Y, Nakatsumi H, Muranaka T, Kobayashi Y, Miyagishima T, Ehira N, Iwanaga I, Okuda H, Tateyama M, Tsuji Y, Hatanaka K, Nakamura M, Kudo M, Fukushima H, Hisai H, Abe R, Sakamoto N, Oba K, Sakata Y.
Randomized controlled trial on the skin toxicity of panitumumab in third line treatment of KRAS Exon2 wild- type mCRC : Japanese Skin Toxicity Evaluation Protocol with Panitumumab: J-STEPP/HGCSG1001 : Updated analysis of anti-tumor efficacy.

Asian Pacific Digestive Week 2015 (APDW2015)
2015.12. Taipei, Taiwan


Kawakubo K, Kawakami H, Kuwatani M, Haba S, Kudo T, Taya Y, Kawahata S, Kubota Y, Kubo K, Eto K, Ehira N, Yamato H, Sakamoto N.
Endoscopic nasobiliary drainage has lower incidence of complications than endoscopic biliary stenting for the management of hilar cholangiocarcinoma.

Sato T, Kitagawa S, Kimura M.
Endoscopic treatments for angiodysplasia of stomach.

Campirobacter, Helicobacter&Related Organism (CHRO)
2015.11. Rotorua, New Zealand


Mabe K, Kato M, Asaka M, Shiratori S.
The endoscopic future of non-Helicobacter pylori helico- bacter gastritis.

AASLD The Liver meeting 2015
2015.11. San Francisco, USA


Hige S, Ozeki I, Yamaguchi M, Kimura M, Arakawa T, Nakajima T, Kuwata Y, Sato T, Ohmura T, Toyota J, Karino Y.
Efficacy and safety of daclatasvir and asunaprevir in patients aged 70 years and older with genotype 1 chronic hepatitis C.

Morikawa K, Shimazaki T, Izumi T, Umemura M, Nakai M, Suda G, D Moradpour and Sakamoto N.
The Hepatitis B virus maintain cellular homeostasis from oxidative stress by autophagy.

Nakai M, Umemura M, Izumi T, Ito J, Tsunematsu S, Sato F, Sho T, Suda G, Morikawa K, Ogawa K, Sakamoto N.
The decreased urinary aquaporin2 excretion is a predictive factor for the efficacy of Tolvaptan in patients with hepatic cirrhosis.

Suda G, Tsunematsu S, Ito Jun, Sato F, Terashita K, Nakai M, Sho T, Natsuizaka M, Morikawa K, Ogawa K, Sakamoto N.
Truncated Hepatitis B virus X protein up-regulates CD44+ cancer stem like cells through LTBP1.

23rd United European Gastroenterology Week (UEGW 2015)
2015.10. Barcelona, Spain


Matsumoto M, Yoshii S, Yoshida M, Shigesawa T, Dazai M, Onodera M, Kato M.
Hemorrhage after therapeutic endoscopy in hemodialysis patients: a multicenter study.

Mizushima T, Ohnishi S, Shimizu Y, Hatanaka Y, Hatanaka K C, Hosono H, Kubota Y, Natsuizaka M, Kamiya M, Ono S, Homma A, Kato M, Sakamoto N, Urano Y.
Fluorescent imaging of superficial head and neck squamous cell carcinoma using a γ-glutamyltranspeptidase-activated probe.

Ono M, Ohnishi S, Ishikawa M, Onishi R, Sakamoto N.
Effect of human amnion-derived mesenchymal stem cell transplantation in rats with radiation proctitis.

Shimizu Y.
Observer agreement among beginners in image assessment of Barrett's esophagus using a simplified narrow-band imaging classification: a retrospective multi-center study.


Kawakubo K, Kawakami H, Kuwatani M, Kawahata S, Kubota Y, Kubo K, Sakamoto N.
A comparative study of endoscopic ultrasound-guided cho- ledochoduodenostomy and transpapillary stent placement in patients with malignant biliary obstruction as the first line treatment.

2015 International HBV meeting
2015.10. Bad Nauheim, Germany


Morikawa K, Shimazaki T, Izumi T, Umemura M, Nakai M, Suda G, Darius M and Sakamoto N.
Dynamic analysis of cellular factors modulated by Hepatitis B virus protein expression and replication.

European Cancer Congress 2015
2015.9. Vienna, Austria


Nakatsumi H, Yuki S, Kawamoto Y, Muranaka T, Hatanaka K, Kato T, Meguro T, Nakamura M, Iwanaga I, Uebayashi M, Tateyama M, Eto K, Kudo M, Kato Sosuke, Okuda H, Sogabe S, Miyashita K, Sakata Y, Sakamoto N, Komatsu Y.
Updated analysis: Observational cohort study of 1st line bevacizumab combined with chemotherapy in metastatic colorectal cancer (HGCSG0802): comparison of infusional FU/oxaliplatin (OX)+BV and oral FU/OX+BV.

Kobayashi Y, Yuki S, Kawamoto Y, Sawada K, Miyagishima T, Ehira N, Iwanaga I, Okuda H, Tateyama M, Tsuji Y, Hatanaka K, Nakamura M, Kudo M, Fukushima H, Takagi T, Hisai H, Koike M, Abe R, Sakata Y, Komatsu Y.
Randomized controlled trial on the toxicity of panitumumab in third line treatment of KRAS Exson2 wild-type metastatic colorectal cancer:HGCSG1001 (Japanese Skin Txicity Evaluation Protocol With Panitumumab:J-STEP):Updated analysis of anti-tumor efficacy.

Nakajima M, Kobayashi Y, Tajima M, Yokoyama S, Nihei M, Nakano S, Hirata H, Kitahara G, Terashita K, Takahashi K, Okada K, Haba S, Sogabe S, Oda H, Miyagishima T.
Retrospective study on the safety and efficacy of cell-free and concentrated ascites reinfusion therapy (CART) for patients with malignant asacites or pleural effusion: analysis of with or without steroid premedication.

Nakamura M, Yuki S, Nakatsumi H, Muto O, Hosokawa A, Kato T, Iwanaga I, Hatanaka K, Tsuji Y,Sato A, Eto K, Furukawa K, Okuda H, Onodera M, Fujikawa K, Kudo M, Yokoyama S, Honda T, Sakata Y, Komatsu Y.
Updated analysis : Phase II trial of Irinotecan plus S-1 (IRIS) with Cetuximab (IRIS/Cet) with KRAS wild type of metastatic colorectal cancer (mCRC) :HGCSG0902

Yagisawa M, Yuki S, Muranaka T, Sawada K, Hatanaka K, Kato T, Megura T, Nakamura M, Iwanaga I, Eto K, Sato A, Okuda H, Kato K, Miyagishima T, Muto O, Yabusaki S, Miyamoto N, Kudo K, Sakata Y, Komatsu Y.
Association of morphologic response with overall survival in patients with metastatic colorectal cancer treated with bevacizumab-based chemotherapy: Updated analysis- HGCSG0802

Endoscopic Forum Japan 2015
2015.8. Tokyo. Japan


Kawakami H.
Selective bile duct cannulation and post-ERCP pancreatitis ?Recent RCTs in Japan?

The 23rd Asia Pacific Cancer Conference (APCC 2015)
2015.8. Bali, Indonesia


Nakano M, Yuki S, Ishioka I, Miyake A, Muranaka T, Sawada K, Nakatsumi H, Kawamoto Y, Komatsu Y.
Single center retrospective study of daily practice use of regorafenib for metastatic colorectal cancer patients.

ESMO World Congress on Gastrointestinal Cancer
2015.7. Barcelona, Spain


Hatanaka K, Yuki S, Nakatsumi H, Hosokawa A, Nakamura M, Muto O, Meguro T, Iwanaga I, Tsuji Y, Sato A, Eto K, Furukawa K, Onodera M, Tateyama M, Takahashi Y, Dazai M, Yokoyama S, Honda T, Okuda H, Kudo M, Sakata Y, Komatsu Y.
Phase II trial of Irinotecan/S-1 (IRIS) with Cetuximab (IRIS/ Cet) as second line treatment in patients with KRAS WT metastatic colorectal cancer: HGCSG0902. -Comparison of administration interval in Cetuximab treatment.

Iwanaga I, Yuki S. Fukushima H, Takahash N, Shichinohe T, Kusumi T, Nakamura F, Sogabe S, Hatanaka K, Oomori K, Misawa K, Senmaru N, Iwai K, Shinohara T, Koike M, Miyashita K, Amano T, Ito M, Sakamoto N, Taketomi A, Hirano S, Komatsu Y.
Safety analysis of FOLFOX as adjuvant chemotherapy for stage III colon cancer in phase II study (NORTH/HGCSG1003) - an analysis of surgeons vs oncologists.

Yuki S, Komatsu Y, Muranaka T, Hayashi H, Yoshida S, Ohta Y, Hatanaka K, Tsuji Y, Kawamoto Y, Yoshizaki K, Sato A, Eto K, Onodera K, Kato S, Nakamura M, Muto O, Abe M, Sato Y, Ishiguro M, Tateyama M, Okuda H, Sakamoto N, Sakata Y.
A retrospective cohort study evaluating the safety and efficacy of regorafenib in patients with metastatic colorectal cancer; the HGCSG1401 study -first report-

International Society for Stem Cell Research 2015
2015.6. Stockholm, Sweden


Kawakubo K, Ohnishi S, Fujita H, Kuwatani M, Masamune A, Ohnishi R, Takeda H, Sakamoto N.
Effect of fetal membrane-derived mesenchymal stem cell transplantation in rats with acute and chronic pancreatitis.

5th International Symposium on Viral Hepatitis and Liver Disease
2015.6. Berlin, Germany


Hige S, Karino Y, Ozeki I, Yamaguchi M, Kimura M, Arakawa T, Nakajima T, Kuwata Y, Sato T, Ohmura T, Toyota J.
Early reduction of serum fibrosis marker and tumor marker in patients treated with daclatasvir and asunaprevir.

Hige S, Ozeki I, Yamaguchi M, Kimura M, Arakawa T, Nakajima T, Kuwata Y, Sato T, Ohmura T, Toyota J, Mizokami M, Narimatsu H, Karino Y.
A unique glycoprotein; Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) is a disease-specific serum marker for liver fibrosis.

2015 ASCO Annual Meeting
2015.5. Chicago, USA


Yuki S, Shitara K, Miki I, Sudo T, Fujii S, Kuwata T, Okamoto W, Denda T, Kajiwara T, Yuki S, Nakajima T.E., Takashima A, Kawasaki K, Tamura T, Esaki T, Yamanaka T, Ochiai A, Doi T, Ohtsu A, Hotta T, Yoshino T.
The nationwide cancer genome screening projects for gastrointestinal cancer in Japan (SCRUM-Japan GI- SCREEN): Efficient identification of actionable cancer genome alterations in advanced colorectal and non- colorectal gastrointestinal cancer (GI Screen 2013-01-CRC and 2015-01-Non CRC).

Yuki S, Yoshino T, Tsuchihara K, Shinozaki E, Muro K, Nishina T, Yamaguchi K, Akagi K, Yamazaki K, Yamanaka T, Nomura S, Fujii S, Esumi H, Abe Y, Ohtsu A.
Clinical impact of expanded BRAF mutational status on the outcome for metastatic colorectal cancer patients with anti-EGFR antibody: An analysis of the BREAC trial (Biomarker research for anti-EGFR monoclonal antibodies by comprehensive cancer genomics).

Digestive Disease Week 2015(DDW 2015)
2015.5. WashingtonD.C, USA


Ohnishi S, Nakagawa K, Okubo N, Sadakane C, Saegusa Y, Nahata M, Yamada C, Hattori T, Sakamoto N, Takeda H.
The hypophagia after psychological stress in aged male mice is mediated by an interaction of activation of estrogen receptor α with serotonin 2C receptor.

Sato F, Natsuizaka M, Maehara O, Asano A, Kubota Y, Itoh J, Tsunematsu S, Tsukuda Y, Terashita K, Nakai M, Sho T, Suda G, Morikawa K, Ogawa K, Ohnishi S, Sakamoto N.
KLF5 promotes tumorigenicity of hepatocellular carcinoma by up-regulation of cancer stem-like cells.


Kawakubo K, Ohnishi S,Urano Y, Hatanaka Y, Hatanaka K, Kawakami H ,Kuwatani M, Kawahata S, Abe Y ,Kubota Y, Kubo K, Sakamoto N.
A novel technique for the detection of endoscopic ultrasound-guided fine needle pancreatic tissue acquisition by anenzymatically rapid-activatable fluorescent probe.

Kubota M, Kawakami H , Natuizaka M , Kawahata S ,Kubo K , Kawakubo K , Kuwatani M, Sakamoto N.
Mutational analysis of pancreatic neuroendocrine tumor using endoscopic ultrasound-guided fine-needle aspiration and next-generation deep sequencing.

Kuwatani M, Kawakami H, Kawakubo K, Kawahata S, Kubo K , Abe Y , Sakamoto N.
Merits and demerits of steroid therapy for IgG4-related sclerosing cholangitis.

Miyamoto S, Kato M, Ono S, Mabe K, Shimizu Y, Sakamoto N, 安孫子 怜史 , 津田 桃子 , 大森 沙織 , 水島 健 , 森 康明 , 中川 学 , 中川 宗一
Novel Gastric gastric mucosal changes induced by use of Proton pump inhibitor.

The 3rd JSGE International Topic Conference
2015.4. Sendai, Japan


Omori S, Kato M, Sakamoto N.
Study about the relationship between human intestinal spirochetosis and sessile serrated adenoma/ polyp.

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