北海道大学大学院 医学研究科内科学講座 消化器内科学分野

Association of gene expression involving innate immunity and genetic variation in IL28B with antiviral response.

Asahina Y, Tsuchiya K, Muraoka M, Tanaka K, Suzuki Y, Tamaki N, Hoshioka Y, Yasui Y, Katoh T, Hosokawa T, Ueda K, Nakanishi H, Itakura J, Takahashi Y, Kurosaki M, Enomoto N, Nitta S, Sakamoto N, Izumi N.

Hepatology. 2011; 55(1):20-29.

IL28B but not ITPA polymorphism is predictive of response to pegylated interferon, ribavirin, and telaprevir triple therapy in patients with genotype 1 hepatitis C.

Chayama K, Hayes CN, Abe H, Miki D, Ochi H, Karino Y, Toyota J, Nakamura Y, Kamatani N, Sezaki H, Kobayashi M, Akuta N, Suzuki F, Kumada H

J Infect Dis. 2011; 204(1): 84-93.

Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders.

Chayama K, Takahashi S, Toyota J, Karino Y, Ikeda K, Ishikawa H, Watanabe H, McPhee F, Hughes E, Kumada H

Hepatology. 2012; 55(3): 742-748.

Let-7b is a novel regulator of hepatitis C virus replication.

Cheng J-C, Yeh YJ, Tseng CP, Hsu SD, Chang YL, Sakamoto N, Huang HD.

Cell Mol Life Sci. 2012;69(15):2621-33.

Efficacy of therapy for advanced hepatocellular carcinoma: intra-arterial 5-fluorouracil and subcutaneous interferon with image-guided radiation.

Chuma M, Taguchi H, Yamamoto Y, Shimizu S, Nakanishi M, Ogawa K, Sho T, Horimoto H, Kobayashi T, Nakai M, Terashita K, Sakuhara Y, Abo D, Tsukuda Y, Tsunematsu S, Hige S, Kato M, Shirato H, Asaka M

J Gastroenterol Hepatol. 2011; 26(7): 1123-1132.

Inhibition of both protease and helicase activities of hepatitis C virus NS3 by an ethyl acetate extract of marine sponge Haliclona (Reniera) sp.

Fujimoto Y, Salam KA, Furuta A, Matsuda Y, Fujita O, Tani H, Ikeda M, Kato N, Sakamoto N, Maekawa S, Enomoto N, de Voogd NJ, Nakakoshi M, Tsubuki M, Sekiguchi Y, Tsuneda S, Akimitsu N, Noda N, Yamashita A, Tanaka J, Moriishi K

Plos One. 2012; 7(11): e48685.

A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan

Fujioka T, Aoyama N, Sakai K, Miwa Y, Kudo M, Kawashima J, Matsubara Y, Miwa J, Yakabi K

Journal of Gastroenterology. 2012; 47(3): 276-283.

Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91.

Funaoka Y, Sakamoto N, Nakagawa M, Kakinuma S, Suda S, Watanabe T, Nitta S, Kitazume A, Kiyohashi K, Murakawa M, Azuma S, Tsuchiya K, and Watanabe M.

J Virol. 2011; 85(12):5986-5994.

Triple Therapy with Ecabet Sodium, Amoxicillin and Lansoprazole for 2 Weeks as the Rescue Regimen for H. pylori Infection.

Furuta T, Kato M, Sugimoto M, Sasaki M, Kamoshida T, Furukawa K, Inaba T, Tomita T, Shirai T, Ishii N, Nomura H, Konda Y, Asaka M; the JAPAN GAST STUDY GROUP.

Intern Med. 2011; 50(5): 369-374.

Sustained-release adrenomedullin ointment accelerates wound healing of pressure ulcers.

Harada K, Yamahara K, Ohnishi S, Otani K, Kanoh H, Ishibashi-Ueda H, Minamino N, Kangawa K, Nagaya N, Ikeda T

Regulatory Peptides. 2011; 168(1-3): 21-26.

Clinical impact of cycling administration of antibiotics for febrile neutropenia in Japanese patients with hematological malignancy.

Hashino S, Morita L, Kanamori H, Takahata M, Onozawa M, Nakagawa M, Kawamura T, Fujisawa F, Kahata K, Izumiyama K, Yonezumi M, Chiba K, Kondo T, Asaka M

Eur J Clin Microbiol Infect Dis. 2012; 31(2): 173-178.

Stent selection and tips on placement technique of EUS-guided biliary drainage: transduodenal and transgastric stenting

Itoi T, Isayama H, Sofuni A, Itokawa F, Kurihara T, Tsuchiya T, Tsuji S, Ishii K, Ikeuchi N, Tanaka R, Umeda J, Moriyasu F, Kawakami H

J Hepatobiliary Pancreat Sci. 2011; 18(5): 664-672.

Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver.

Itoi T, Isayama H, Sofuni A, Itokawa F, Tamura M, Watanabe Y, Moriyasu F, Kahaleh M, Habib N, Nagao T, Yokoyama T, Kasuya K, Kawakami H

J Hepatobiliary Pancreat Sci. 2012; 19(5): 543-547.

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture.

Kalabis J, Wong GS, Vega ME, Natsuizaka M, Robertson ES, Herlyn M, Nakagawa H, Rustgi AK

Nat Protoc. 2012; 7(2): 235-246.

Adjuvant therapy with imatinib mesylate after resection of primary high-risk gastrointestinal stromal tumors in Japanese patients.

Kanda T, Nishida T, Wada N, Kobayashi O, Yamamoto M, Sawaki A, Boku N, Koseki M, Doi T, Toh Y, Kakeji Y, Sugiyama T, Komatsu Y, Kikuchi S, Ogoshi K, Katai H, Miyachi K, Hirota S, Ohtsu A

Int J Clin Oncol. 2011; ♂EPub ahead of Print♀

Professional oral health care reduces oral mucositis and febrile neutropenia in patients treated with allogeneic bone marrow transplantation.

Kashiwazaki H, Matsushita T, Sugita J, Shigematsu A, Kasashi K, Yamazaki Y, Kanehira T, Yamamoto S, Kondo T, Endo T, Tanaka J, Hashino S, Nishio M, Imamura M, Kitagawa Y, Inoue N

Support Care Cancer. 2012; 20(2): 367-373.

Phase II study of chemoradiotherapy with 5-fluorouracil and cisplatin for Stage II-III esophageal squamous cell carcinoma: JCOG trial (JCOG 9906).

Kato K, Muro K, Minashi K, Ohtsu A, Ishikura S, Boku N, Takiuchi H, Komatsu Y, Miyata Y, Fukuda H

Int J Radiat Oncol Biol Phys. 2011; 81(3): 684-690.

Preoperative biliary drainage for hilar cholangiocarcinoma: which stent should be selected?

Kawakami H, Kondo S, Kuwatani M, Yamato H, Ehira N, Kudo T, Eto K, Haba S, Matsumoto J, Kato K, Tsuchikawa T, Tanaka E, Hirano S, Asaka M

J Hepatobiliary Pancreat Sci. 2011; 18(5): 630-635.

A muticenter prospective randomized study of selective bile duct cannulation performed by multiple endoscopists: The BIDMEN study

Kawakami H, Maguchi H, Mukai T, Hayashi T, Sasaki T, Isayama H, Nakai Y, Yasuda I, Irisawa A, Niido T, Okabe Y, Ryozaa S, Itoi T, Hanada K, Kikuyama M, Arisaka Y, Kikuchi S, for the Japan Bile Duct Cannulation Study Group

Gastointestinal Endoscopy. 2012; 75(2): 362-372.

Anemia and thrombocytosis induced by ribavirin monotherapy in patients with chronic hepatitis C.

Kobayashi T, Hige S, Terashita K, Nakai M, Horimoto H, Sho T, Nakanishi M, Ogawa K, Chuma M, Sakamoto N, Asaka M

J Gastroenterol. 2012; 47(11): 1228-1237.

Phase II study of combined treatment with irinotecan and S-1 (IRIS) in patients with inoperable or recurrent advanced colorectal cancer (HGCSG0302).

Komatsu Y, Yuki S, Sogabe S, Fukushima H, Iwanaga I, Kudo M, Tateyama M, Meguro T, Uebayashi M, Saga A, Sakata Y, Asaka M

Oncology. 2011; 80(1): 70-75.

Randomized phase II trial of first-line treatment with tailored irinotecan and S-1 therapy versus S-1 monotherapy for advanced or recurrent gastric carcinoma (JFMC31-0301).

Komatsu Y, Takahashi Y, Kimura Y, Oda H, Tajima Y, Tamura S, Sakurai J, Wakasugi T, Tatebe S, Takahashi M, Sakata Y, Kitajima M, Sakamoto J, Saji S

Anticancer Drugs. 2011; 22(6): 576-583.

Age and total ribavirin dose is an independent predictor of relapse among early virological responders to peg-interferon plus ribavirin therapy in chronic hepatitis C revealed by data mining analysis.

Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, Iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sugauchi F, Sakamoto N, Nakagawa M, Yatsuhashi H, Izumi N.

Antivir Ther. 2012; 17:35-43.

Data mining model using simple and readily available factors could identify patients at high risk for hepatocellular carcinoma in chronic hepatitis C.

Kurosaki M, Hiramatsu N, Sakamoto M, Suzuki Y, iwasaki M, Tamori A, Matsuura K, Kakinuma S, Sugauchi F, Sakamoto N, Nakagawa M, Izumi N.

J Hepatol. 2012;56(3):602-608.

Sequences in the interferon sensitivity-determining region and core region of hepatitis C virus impact pretreatment prediction of response to PEG-interferon plus ribavirin: data mining analysis.

Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Hiramatsu N, Sugauchi F, Tamori A, Nakagawa M, Izumi N.

J Med Virol. 2011;83:445-452.

A model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C.

Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Matsuura K, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Tokunaga K, Mizokami M, Izumi N

J Med Virol. 2013; ♂in press♀.

Identification of novel N-(morpholine-4-carbonyloxy) amidine compounds as potent inhibitors against hepatitis C virus replication.

Kusano-Kitazume A, Sakamoto N, Okuno Y, Sekine-Osajima Y, Nakagawa M, Kakinuma S, Kiyonashi K, Nitta S, Murakawa M, Azuma S, Nishimura-Sakurai Y, Hagiwara M, Watanabe M.

Antimicrob Agent Chemother. 2012; 56(3):1315-1323.

Carbon dioxide insufflation during endoscopic retrograde cholangiopancreatography reduces bowel gas volume but does not affect visual analogue scale scores of suffering: a prospective, double-blind, randomized, controlled trial.

Kuwatani M, Kawakami H, Hayashi T, Ishiwatari H, Kudo T, Yamato H, Ehira N, Haba S, Eto K, Kato M, Asaka M

Surgical Endoscopy. 2011; 25(12): 3784-3790.

Cyclophilin A and nuclear factor of activated T cells are essential in cyclosporin A-mediated suppression of polyomavirus BK replication.

Li YJ, Wu HH, Weng CH, Chen YC, Hung CC, Yang CW, Wang YL, Sakamoto N, Tian YC

Am J Transplantation. 2012; 12: 2348-2362.

Combination of hepatitis B viral antigens and DNA for prediction of relapse after discontinuation of nucleos(t)ide analogs in patients with chronic hepatitis B.

Matsumoto A, Tanaka E, Suzuki Y, Kobayashi M, Tanaka Y, Shinkai N, Hige S, Yatsuhashi H, Nagaoka S, Chayama K, Tsuge M, Yokosuka O, Imazeki F, Nishiguchi S, Saito M, Fujiwara K, Torii N, Hiramatsu N, Karino Y, Kumada H

Hepatology Research. 2012; 42(2): 139-149.

Phase I dose-escalating study of panobinostat (LBH589) Administered intravenously to Japanese patients with advanced solid tumors.

Morita S, Oizumi S, Minami H, Kitagawa K, Komatsu Y, Fujiwara Y, Inada M, Yuki S, Kiyota N, Mitsuma A, Sawaki M, Tanii H, Kimura J, Ando Y

Invest New Drugs. 2012; 30(5): 1950-1957.

Association of ITPA gene variant and serum ribavirin concentration with blood cells decline in pegylated interferon-alfa plus ribavirin therapy for chronic hepatitis C.

Nakagawa M, Sakamoto N, Watanabe T, Nishimura-Sakurai Y, Onozuka Y, Azuma S, Kakinuma S, Nitta S, Kiyohashi K, Kusano-Kitazume A, Murakawa M, Yoshino K, Itsui Y, Tanaka Y, Mizokami M, Watanabe M, Ochanomizu Liver Conference Study Group.

Hepatol Int. 2012; ♂EPub ahead of Print♀.

Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow.

Nakanishi C, Nagaya N, Ohnishi S, Yamahara K, Takabatake S, Konno T, Hayashi K, Kawashiri M, Tsubokawa T, Yamagishi M

Circulation Journal. 2011; 75(9): 2260-2268.

Relationship Between Diffusion-Weighted Magnetic Resonance Imaging and Histological Tumor Grading of Hepatocellular Carcinoma.

Nakanishi M, Chuma M, Hige S, Omatsu T, Yokoo H, Nakanishi K, Kamiyam T, Kubota K, Haga H, Matsuno Y, Onodera Y and Kato M and Asaka M

Ann Surg Oncol. 2012; 19(4): 1302-1309.

Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives.

Nichols DB, Fournet G, Gurukumar KR, Basu A, Lee JC, Sakamoto N, Kozielski F, Musmuca I, Joseph B, Ragno R, Kaushik-Basu N.

Eur J Med Chem. 2012; 49:191-199.

Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity.

Nitta S, Sakamoto N, Nakagawa M, Kakinuma S, Mishima K, Kusano-Kitazume A, Kiyohashi K, Murakawa M, Nishimura-Sakurai Y, Azuma S, Tasaka-Fujita M, Yoneyama M, Fujita T, Watanabe M.

Hepatology. 2012; ♂EPub ahead of Print♀.

A Notch3-mediated squamous cell differentiation program limits expansion of EMT competent cells that express the ZEB transcription factors.

Ohashi S＊, Natsuizaka M＊, Naganuma S＊ (＊ co-first authors), Kagawa S, Kimura S, Itoh H, Kalman RA, Nakagawa M, Darling DS, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Herlyn M, Nakagawa H

Cancer Res. 2011; 71(21): 6836-6847.

Macrophage migration inhibitory factor contributes to development of nonsteroidal anti-inflammatory drugs-induced gastric injury in mice.

Ohkawara T, Takeda H, Ohnishi S, Kato M, Nishihira J, Asaka M

Int Immunopharmacol. 2011; 11(4): 418-423.

EUS-FNA for suspected malignant biliary strictures after negative endoscopic transpapillary brush cytology and forceps biopsy.

Ohshima Y, Yasuda I, Kawakami H, Kuwatani M, Mukai T, Iwashita T, Doi S, Nakashima M, Hirose Y, Asaka M, Moriwaki H

J Gastroenterol. 2011; 46(7): 921-928.

Target biopsy using magnifying endoscopy in clinical management of gastric mucosa-associated lymphoid tissue lymphoma.

Ono S, Kato M, Ono Y, Nishida U, Yamamoto K, Shimizu Y, Asaka M

J Gastroenterol Hepatol. 2011; 26(7): 1133-1138.

Endoscopic ultrasound-guided transmural drainage for pancreatic fistula or pancreatic duct dilatation after pancreatic surgery.

Onodera M, Kawakami H, Kuwatani M, Kudo T, Haba S, Abe Y, Kawahata S, Eto K, Nasu Y, Tanaka E, Hirano S, Asaka M

Surgical Endoscopy. 2012; 26(17): 1710-1717.

The 8p11 myeloproliferative syndrome owing to rare FGFR1OP2-FGFR1 fusion.

Onozawa M, Ohmura K, Ibata M, Iwasaki J, Okada K, Kasahara I, Yamaguchi K, Kubota K, Fujisawa S, Shigematsu A, Endo T, Kondo T, Hashino S, Tanaka J, Matsuno Y, Asaka M, Imamura M

Eur J Haematol. 2011; 86(4): 347-349.

A multi-center survey of re-treatment with pegylated interferon plus ribavirin combination therapy for patients with chronic hepatitis C in Japan.

Oze T, Hiramatsu N, Mita E, Akuta N, Sakamoto N, Itoh Y, Izumi N, Nomura H, Hayashi N, Takehara T

Hepatol Res. 2012; ♂in press♀.

Antiviral effects of peginterferon alpha-2b and ribavirin following 24-week monotherapy of telaprevir in Japanese hepatitis C patients.

Ozeki I, Akaike J, Karino Y, Arakawa T, Kuwata Y, Ohmura T, Sato T, Kamiya N, Yamada I, Chayama K, Kumada H, Toyota J

J Gastroenterol. 2011; 46(7): 929-937.

10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation.

Sadakane C, Muto S, Nakagawa K, Ohnishi S, Saegusa Y, Nahata M, Hattori T, Asaka M, Takeda H

Biochem Biophys Res Commun. 2011; 412(3): 506-511.

Suppression of hepatitis C virus replicon by adenovirus vector-mediated expression of tough decoy RNA against miR-122a.

Sakurai F, Furukawa N, Higuchi M, Okamoto S, Ono K, Yoshida T, Kondoh M, Yagi K, Sakamoto N, Katayama K, Mizuguchi H.

Virus Research. 2012; 165(2):214-218

Decreased motility of the lower esophageal sphincter in a rat model of gastroesophageal reflux disease may be mediated by reductions of serotonin and acetylcholine signaling.

Saegusa Y, Takeda H, Muto S, Oridate N, Nakagawa K, Sadakane C, Nahata M, Harada Y, Iizuka M, Hattori T, Asaka M

Biol Pharm Bull. 2011; 34(5): 704-711.

Decreased plasma ghrelin contributes to anorexia following novelty stress.

Saegusa Y, Takeda H, Muto S, Nakagawa K, Ohnishi S, Sadakane C, Nahata M, Hattori T, Asaka M

Am J Physiol Endocrinol Metab. 2011; 301(4): E685-696.

Phase I study of concurrent real-time tumor-tracking thoracic radiation therapy with paclitaxel and carboplatin in locally advanced non-small cell lung cancer.

Sakakibara-Konishi J, Oizumi S, Kinoshita I, Shinagawa N, Kikuchi J, Kato M, Inoue T, Katoh N, Onimaru R, Shirato H, Dosaka-Akita H, Nishimura M

Lung Cancer. 2011; 74(2): 248-252.

Association of IL28B variants with response to pegylated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypic differences between genotypes 2a and 2b.

Sakamoto N, Nakagawa M, Tanaka Y, Sekine-Osajima Y, Ueyama M, Kurosaki M, Nishida N, Tamori A, Yuki NS, Itsui Y, Azuma S, Kakinuma S, Hige S, Itoh Y, Tanaka E, Hiasa Y, Izumi N, Tokunaga K, Mizokami M, Watanabe M.

J Med Virol. 2011;83:871-878.

"Romiplostim for the treatment of chronic immune thrombocytopenia in adult Japanese patients: a double-blind, randomized Phase III clinical trial."

Shirasugi Y, Ando K, Miyazaki K, Tomiyama Y, Okamoto S, Kurokawa M, Kirito K, Yonemura Y, Mori S, Usuki K, Iwato K, Hashino S, Wei H, Lizambri R

Int J Hematol. 2011; 94(1): 71-80.

Sensitivity to previous irinotecan treatment does not predict the efficacy of combination chemotherapy with cetuximab plus irinotecan for wild-type KRAS metastatic colorectal cancer.

Shitara K, Ura T, Matsuo K, Takahari D, Yokota T, Yuki S, Yoshida M, Utsunomiya S, Sato Y, Yamaura H, Kato M, Inaba Y, Tajika M, Kawai H, Yamazaki K, Komatsu Y, Muro K

Eur J Cancer. 2011; 47(18): 2673-2680.

Endoscopic pancreatic duct stents reduce the incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis in high risk patients

Sofuni A, Maguchi H, Mukai T, Kawakami H, Irisawa A, Kubota K, Okaniwa S, Kikuyama M, Kusumi H, Hanada K, Ueki T, Itoi T

Clin Gastroenterol Hepatol. 2011; 9(10): 851-858.

Retrospective cohort study on the safety and efficacy of bevacizumab with chemotherapy for metastatic colorectal cancer patients: the HGCSG0801 study.

Sogabe S, Komatsu Y, Yuki S, Kusumi T, Hatanaka K, Nakamura M, Kato T, Miyagishima T, Hosokawa A, Iwanaga I, Sakata Y, Asaka M

Jpn J Clin Oncol. 2011; 41(4): 487-490.

Efficacy of folic acid in preventing oral mucositis in allogeneic stem cell transplant patients receiving MTX as prophylaxis for GVHD.

Sugita J, Matsushita T, Kashiwazaki H, Kosugi M, Takahashi S, Wakasa K, Shiratori S, Ibata M, Ahono Y, Shigematsu A, Obara M, Fujimoto K, Endo T, Nishio M, Kondo T, Hashino S, Tanaka J, Asaka M, Imamura M

Bone Marrow Transplant. 2012; 47(2): 258-264.

Inhibition of hepatitis C virus replication and viral helicase by ethyl acetate extract of the marine feather star Alloeocomatella polycladia.

Yamashita A, Abdus K, Furuta A, Matsuda Y, Fujita O, Tani H, Fujita Y, Fujimoto Y, Ikeda M, Kato N, Sakamoto N, Maekawa S, Enomoto N, Nakakoshi M, Tsubuki M, Sekiguchi Y, Thuneda S, Akimitsu N, Noda N, Tanaka J, Moriishi K.

Marine Drugs. 2012; 10(4):744-61.