スタッフ紹介

助教山本 桂子

Keiko Yamamoto

専門分野

消化管、内視鏡、診断・治療

助教　山本 桂子

学歴

1995年3月
札幌南高等学校卒業
2002年3月
弘前大学医学部医学科卒業
2011年3月
北海道大学医学部大学院医学研究科医学専攻博士課程

職務経歴

2002年5月
北海道大学医学部附属病院医員　研修医
2003年4月
札幌北楡病院　研修医
7月
砂川市立病院　研修医
2004年4月
釧路労災病院内科　医員
2006年4月
北見赤十字病院消化器内科
2007年4月
北海道大学病院第三内科（消化器内科）　院生医員
2011年4月
恵佑会札幌病院消化器内科　医師
2013年4月
市立函館病院消化器内科　医長
2016年4月
北海道大学病院光学医療診療部　医員
2018年4月
北海道大学病院光学医療診療部　助教

所属学会・資格

  • 日本内科学会　認定内科医、総合内科専門医
  • 日本消化器病学会　専門医、指導医・北海道支部評議員、学会評議員
  • 日本消化器内視鏡学会　専門医・指導医・北海道支部評議員
  • 日本ヘリコバクター学会　ピロリ菌感染症認定医
  • 日本大腸検査学会
  • 日本胃癌学会
  • 日本消化管学会

受賞歴・研究助成歴

  • 第107回日本消化器病学会北海道支部奨励賞
  • 2017～19年度　学術研究助成基金助成金　基盤研究（C）
  • 2019年度　伊藤医薬学術交流財団海外学会助成
  • 2021年度　日本消化器内視鏡学会北海道支部研究助成
  • 2020～22年度　学術研究助成基金助成金　基盤研究（C）
  • 2021年度　橋渡し研究戦略的推進プログラム　シーズA
  • 2023年度　内視鏡医学研究振興財団　研究助成B
  • 2023～25年度　学術研究助成基金助成金　基盤研究（C）

特許出願

  • 特願2022-029337
    【発明の名称】処置部材形成剤
  • 国際特許出願 PCT/JP2023/007227
    【発明の名称】処置部材形成剤

業績

  1. Kato M, Nishida U, Nishida M, Hata T, Asaka R, Haneda M, Yamamoto K, Imai A, Yoshida T, Ono S, Shimizu Y, Asaka M.
    Pathophysiological classification of functional dyspepsia using a novel drinking-ultrasonography test.
    Digestion. 82(3), 162-166, 2010
  2. Kato M, Kamada G, Yamamoto K, Nishida U, Imai A, Yoshida T, Ono S, Nakagawa M, Nakagawa S, Shimizu Y, Asaka M.
    Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: double-blinded, placebo controlled study.
    J Gastroenterol Hepatol. 25(10), 1631-1635, 2010
  3. Hige S, Yamamoto Y, Yoshida S, Kobayashi T, Horimoto H, Yamamoto K, Sho T, Natsuizaka M, Nakanishi M, Chuma M, Asaka M.
    Sensitive assay for quantification of hepatitis B virus mutants by use of a minor groove binder probe and peptide nucleic acids.
    J Clin Microbiol. 48(12), 4487-4494, 2010
  4. Yamamoto K, Kato M, Takahashi M, Haneda M, Shinada K, Nishida U, Yoshida T, Sonoda N, Ono S, Nakagawa M, Mori Y, Nakagawa S, Mabe K, Shimizu Y, Moriya J, Kubota K, Matsuno Y, Shimoda T, Watanabe H, Asaka M.
    Clinicopathological Analysis of Early-Stage Gastric Cancers of Detected After Successful Eradication of Helicobacter pylori.
    Helicobacter. 16(3): 210-216, 2011
  5. Ono S, Kato M, Ono Y, Nishida U, Yamamoto K, Shimizu Y, Asaka M.
    Target biopsy using magnifying endoscopy in clinical management of gastric mucosa-associated lymphoid tissue lymphoma.
    J Gastroenterol Hepatol. 26(7), 1133-1138, 2011
  6. Ono S, Kato M, Nakagawa M, Imai A, Yamamoto K, Shimizu Y.
    Outcomes and predictive factors of "not self-completion" in gastric endoscopic submucosal dissection for novice operators.
    Surg Endosc. 27(10), 3577-3583, 2013
  7. Miyamoto S, Kato M, Tsuda M, Matsuda K, Muranaka T, Abiko S, Ono M, Mizushima T, Omori S, Yamamoto K, Mabe K, Ono S, Kudo T, Shimizu Y, Sakamoto N.
    Gastric mucosal cracked and cobblestone-like changes by the use of proton pump inhibitors.
    Dig Endosc. 29: 307-313, 2017
  8. Miyamoto S, Kudo T, Kato M, Matsuda K, Abiko S, Tsuda M, Mizushima T, Yamamoto K, Ono S, Shimizu Y, Sakamoto N.
    Endoscopic ultrasonography features of gastric mucosal cobblestone-like changes from a proton-pump inhibitor.
    Clin J Gastroenterol. 10(3): 220-223, 2017
  9. Miyamoto S, Kato K, Matsuda K, Abiko S, Tsuda M, Mizushima T, Yamamoto K, Ono S, Kudo T, Shimizu Y, Hatanaka K, Tsunematsu I, Sakamoto N.
    Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection.
    Intern Med 56. 1825-1829, 2017
  10. Matsuda K, Ono S, Ishikawa M, Miyamoto S, Abiko S, Tsuda M, Yamamoto K, Kudo T, Shimizu Y, Hayase E, Hashimoto D, Teshima T, Matsuno Y, Sakamoto N.
    Cecum ulcer is a reliable endoscopic finding in cytomegalovirus colitis concomitant with graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
    Ann Hematol. 97:877-883, 2018
  11. Abiko S, Shimizu Y, Miyamoto S, Ishikawa M, Matsuda K, Tsuda M, Mizushima T, Yamamoto K, Ono S, Kudo T, Ono K, Sakamoto N.
    Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk.
    J Gastroenterol. 53:1120-1130, 2018
  12. Mizushima T, Ohnishi S, Shimizu Y, Hatanaka Y, Hatanaka KC, Kuriki Y, Kamiya M, Homma A, Yamamoto K, Ono S, Urano Y, Sakamoto N.
    Rapid detection of superficial head and neck squamous cell carcinoma by topically spraying fluorescent probe targeting dipeptidyl peptidase-IV.
    Head Neck. 40:1466-1475, 2018
  13. Tsuda M, Kato M, Ono S, Matsuda K, Miyamoto S, Abiko S, Ono M, Mizushima T, Yamamoto K, Nakagawa M, Mabe K, Nakagawa S, Kudo T, Nishikawa K, Shimizu Y, Asaka M, Sakamoto N.
    Changes of Dyspeptic Symptom after Successful Eradication in Helicobacter pylori-Associated Dyspepsia.
    Digestion. 2019 Apr 16:1-9. doi: 10.1159/000497432.
  14. Ono S, Ishikawa M, Matsuda K, Tsuda M, Yamamoto K, Shimizu Y, Sakamoto N.
    Clinical impact of the perioperative management of oral anticoagulants in bleeding after colonic endoscopic mucosal resection.
    BMC Gastroenterol. 2019 Dec 2;19(1):206. doi: 10.1186/s12876-019-1124-8.
  15. Yamamoto K, Ohnishi S, Mizushima T, Kodaira J, Ono M, Hatanaka Y, Hatanaka K, Kuriki Y, Kamiya M, Ehira N, Shinada K, Takahashi H, Shimizu Y, Urano Y, Sakamoto N
    Detection of early adenocarcinoma of the esophagogastric junction by spraying an enzyme-activatable fluorescent probe targeting Dipeptidyl peptidase-IV.
    BMC Cancer20(1):64, 2020, Published online 2020 Jan 28. doi: 10.1186/s12885-020-6537-9.
  16. Matsuda K, Ono S, Tanaka I, Inoue M, Kinowaki S, Tsuda M, Yamamoto K, Shimizu Y, Takahashi S, Hayase E, Hashimoto D, Teshima T, Sakamoto N.
    Histological and magnified endoscopic evaluation of villous atrophy in gastrointestinal graft-versus-host disease.
    Annals of Hematology. 99, 1121-1128, 2020ei
  17. Kinowaki S, Shimizu Y, Ono M, ZiJian Y, Tanaka I, Shimoda Y, Inoue M, Ishikawa M, Yamamoto K, Ono S, Ohnishi S, Sakamoto N.
    Experiment on endoscopic balloon dilation for esophageal stenosis after endoscopic submucosal dissection in pigs.
    J Gastroenterol. 2021 Jun;56(6):527-536. doi: 10.1007/s00535-021-01791-2.
  18. Kanno-Okada H, Takahashi K, Katano H, Shimizu A, Takakuwa E, Miyamoto S, Abiko S, Yamamoto K, Shimoda T, Mitsuhashi T, Hasegawa H, Matsuno Y.
    A case of Epstein-Barr virus-associated lymphoepithelioma-like carcinoma of the colon.
    Pathol Int. 2021 Jun;71(6):420-426.
  19. Ikko　Tanaka , Shoko Ono , Yoshihiko Shimoda , Masaki Inoue , Sayoko Kinowaki , Momoko Tsuda , Masayoshi Ono , Keiko Yamamoto, Yuichi Shimizu , Mototsugu Kato , Naoya Sakamoto.
    Eradication of Helicobacter pylori may improve dyspepsia in the elderly for the long term.
    Eur J Gastroenterol Hepatol. 2021 Mar 1;33(3):358-363.
  20. Ono S, Shimoda Y, Tanaka I, Kinowaki S, Inoue M, Ono M, Yamamoto K, Shimizu Y, Sakamoto N.K.
    Optical effect of spraying l-menthol on gastric intestinal metaplasia visualized by linked color imaging.
    Eur J Gastroenterol Hepatol. 2021 Mar 1;33(3):358-363.
  21. Yoshihiko Shimoda, Yuichi Shimizu, Hiroaki Takahashi, Satoshi Okahara4, Takakazu Miyake, Shin Ichihara, Ikko Tanaka, Masaki Inoue, Sayoko Kinowaki, Masayoshi Ono, Keiko Yamamoto, Shoko Ono and Naoya Sakamoto.
    Optical biopsy for esophageal squamous cell neoplasia by using endocytoscopy.
    BMC Gastroenterol. 2022 May 21;22(1):259.
  22. Ono S, Ieko M, Tanaka I, Shimoda Y, Ono M, Yamamoto K, Sakamoto N.
    Bleeding After Gastric Endoscopic Submucosal Dissection Focused on Management of Xa Inhibitors.
    J Gastric Cancer. 2022 Mar;22(1):47-55. doi: 10.5230/jgc.2022.22.e2. Epub 2022 Feb 23.
    PMID: 35425658 Free PMC article.
  23. Tanaka I, Ono S, Watanabe Y, Yamamoto H, Oikawa R, Matsumoto S, Kubo M, Nishimura Y, Shimoda Y, Ono M, Yamamoto K, Sakamoto N.
    Long-term changes in aberrant DNA methylation and gastritis after Helicobacter pylori eradication focused on metachronous gastric cancer.
    Helicobacter. 2022 Oct;27(5):e12915. doi: 10.1111/hel.12915. Epub 2022 Aug 8.
    PMID: 35939560.
  24. Kubo M, Ono S, Yokota I, Matsumoto S, Nishimura Y, Ono M, Yamamoto K, Sakamoto N.
    Quantitative diagnostic algorithm using endocytoscopy for superficial nonampullary duodenal epithelial tumors.
    J Gastroenterol Hepatol. 2023 May 2. doi: 10.1111/jgh.16207. Online ahead of print.
    PMID: 37129220.
  25. Higashino M, Ono S, Matsumoto S, Kubo M, Yasuura N, Hayasaka S, Tanaka I, Shimoda Y, Nishimura Y, Ono M, Yamamoto K, Ono Y, Sakamoto N.
    Improvement of detection sensitivity of upper gastrointestinal epithelial neoplasia in linked color imaging based on data of eye tracking.
    J Gastroenterol Hepatol. 2023 May;38(5):710-715. doi: 10.1111/jgh.16106. Epub 2023 Jan 23.
    PMID: 36627106.
  26. Hirao M, Katada C, Yokoyama T, Yano T, Suzuki H, Furue Y, Yamamoto K, Doyama H, Koike T, Tamaoki M, Kawata N, Kawahara Y, Katagiri A, Ogata T, Yamanouchi T, Kiyokawa H, Kawakubo H, Konno M, Ishikawa H, Yokoyama A, Muto M.
    Metachronous primary gastric cancer after endoscopic resection in patients with esophageal squamous cell carcinoma.
    Gastric Cancer. 2023 Jun 27. doi: 10.1007/s10120-023-01413-1. Online ahead of print.
    PMID: 37368170.
  27. Katada C, Yokoyama T, Mure K, Doyama H, Nakanishi H, Shimizu Y, Yamamoto K, Furue Y, Tamaoki M, Koike T, Kawahara Y, Kiyokawa H, Konno M, Yokoyama A, Ohashi S, Ishikawa H, Yokoyama A, Muto M.
    Risk factors for the development of second primary esophageal squamous-cell carcinoma after endoscopic resection for esophageal squamous-cell carcinoma according to genetic polymorphisms related to alcohol and nicotine metabolism.
    Jpn J Clin Oncol. 2023 Jun 27:hyad070. doi: 10.1093/jjco/hyad070. Online ahead of print.
    PMID: 37370215.
  28. Katada C, Yokoyama T, Yano T, Suzuki H, Furue Y, Yamamoto K, Doyama H, Koike T, Tamaoki M, Kawata N, Hirao M, Kawahara Y, Ogata T, Katagiri A, Yamanouchi T, Kiyokawa H, Kawakubo H, Konno M, Yokoyama A, Ohashi S, Kondo Y, Kishimoto Y, Kano K, Mure K, Hayashi R, Ishikawa H, Yokoyama A, Muto M.
    Alcohol consumption, multiple Lugol-voiding lesions, and field cancerization.
    DEN Open. 2023 Jul 3;4(1):e261. doi: 10.1002/deo2.261. eCollection 2024 Apr.
  29. Yusuke Watanabe , Keiko Yamamoto* , Zijian Yang , Haruna Tsuchibora , Masakazu Fujii , Masayoshi Ono, Shoko Ono, Takayuki Kurokawa , Naoya Sakamoto.
    Novel endoscopic management of gastroenterological anastomosis leakage by injecting gel-forming solutions: an experimental animal study.
    Surg Endosc. 37(10):8029-8034. 2023.